Magazine - eLife
Dec 11, 2024 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
How to measure and evaluate binding affinities | eLife
Aug 6, 2020 · First, we asked if equilibration was demonstrated. By definition, an equilibrium state is invariant with time. So, determining a binding equilibrium constant requires showing that there is no change in the amount of bound complex over time.
Microbiome: Balancing microbial composition through diet | eLife
Nov 20, 2024 · The gut of animals is a complex ecosystem consisting of trillions of bacteria and other microorganisms that are unique to every individual. Infants can inherit their first gut bacteria through vaginal birth and breastfeeding, and the microbiome is later reshaped through diet (Ames et al., 2023).The gut microbiome helps to break down and enhance the absorption of nutrients like carbohydrates ...
Endosomal-lysosomal organellar assembly (ELYSA) structures
Jul 26, 2024 · eLife assessment. This paper reports important findings on giant organelle complexes containing endosomes and lysosomes (termed endosomal-lysosomal organelles form assembly structures [ELYSAs]) present in mouse oocytes and 1- to 2-cell embryos. The data showing the localization and dynamics of ELYSAs during oocyte/embryo maturation are convincing.This work will be of interest to general cell ...
About - eLife
eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.
Latest research | eLife
Dec 4, 2024 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
About | eLife Assessments · eLife
eLife changed its approach to peer review in 2023 to better convey the assessments made by editors and reviewers. Every Reviewed Preprint published in the journal now includes an eLife Assessment written by the editor who oversaw the review process and the peer reviewers.
A novel machine learning algorithm selects proteome signature to ...
Mar 26, 2024 · To identify universal exosomal protein biomarkers for differentiating cancer from non-cancer exosomes, we analyzed protein abundance data from 228 cancer and 57 control cell-line-derived exosomes, representing various cancer types (Figure 1A; Supplementary file 1).Because studies employ distinct isolation and mass spectrometry quantification techniques, the number of identified proteins is ...
Hematopoiesis: Counting blood precursors - eLife
Jul 17, 2024 · Experiments with the Confetti reporter system in mice revealed that hundreds of HSPCs in the embryo contribute to hematopoiesis in adults, and that expansion of these precursors is limited in the fetal liver (Ganuza et al., 2017; Ganuza et al., 2022).However, the previous mathematical model used to quantify the number of precursors was only tested for cell counts between 50 and 2,500 cells ...
Epigenetics: Linking environmental factors and gene regulation
Mar 18, 2024 · Finally, the team explored whether methylation changes linked to early life stressors could influence gene regulation. To do so, they used data from 27 studies and compiled a list of genomic regions whose methylation levels are associated with adverse childhood events.