WNT5A transforms intestinal CD8αα+ IELs into an …
Dec 10, 2015 · A majority of IELs express CD8α homodimer together with other molecules associated with immune regulation. Growing evidence points to the WNT signaling pathway as a pivotal piece in the immune balance and focuses on its direct regulation in intestinal epithelium.
Senescent cells perturb intestinal stem cell differentiation through ...
Jan 11, 2023 · Cytosolic Ca 2+ oscillations in intestinal organoids. Wnt5a-mediated noncanonical signaling elicits cytoskeletal changes through activation of Rho and Rac GTPases and modulation of cytosolic Ca...
Wnt signaling in intestinal inflammation - ScienceDirect
Jul 1, 2019 · The strongest evidence outlines a central role of WNT5A in the regulation of cytokines in various cell types, including epithelia, endothelia, and immune cells. Interestingly, WNT5A is a non-canonical Wnt ligand, i.e. it does not signal through β-catenin.
Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt ... - Science
Sep 6, 2012 · We used an in vitro system to enrich for intestinal epithelial stem cells to discover that Wnt5a inhibited proliferation of these cells. Surprisingly, the effects of Wnt5a were mediated by activation of transforming growth factor–β (TGF-β) signaling.
FoxL1+ mesenchymal cells are a critical source of Wnt5a for …
Mar 1, 2021 · Wnt5a is a non-canonical Wnt ligand that is essential for normal embryonic development in mammals. The role of Wnt5a in early intestinal development has been examined in gene ablation models, where Wnt5a −/− mice exhibit strikingly shortened intestines.
HIF2 Regulates Intestinal Wnt5a Expression - PubMed
Nov 25, 2021 · Treatment with recombinant Wnt5a prior to irradiation rescued the cryptogenic capacity of Wnt5a knockout organoids, indicating that Wnt5a is necessary and sufficient for duodenal radioprotection. Taken together, our results suggest that HIF2 radioprotects the GI tract by inducing Wnt5a expression.
HES1 deficiency impairs development of human intestinal …
May 7, 2023 · In CCD-18Co intestinal fibroblast cell lines, overexpression of HES1 led to upregulation of WNT5A expression, which was important for cell proliferation and migration. Our results suggest a critical role for HES1 in both epithelial differentiation and mesenchymal development of human mucosa.
Wnt5a is essential for intestinal elongation in mice - PMC
Feb 2, 2009 · Here, we demonstrate that Wnt5a, a member of the Wnt family of secreted proteins, is essential for the development and elongation of the small intestine from the midgut region. We found that the small intestine in mice lacking Wnt5a was dramatically shortened and duplicated, forming a bifurcated lumen instead of a single tube. In addition, cell ...
Wnt5A Signaling Regulates Gut Bacterial Survival and T Cell …
In view of the fact that the Peyer’s patches of the small intestine constitute a major hub for gut-resident commensal bacteria and phagocytes (21, 22, 37,– 39), we investigated the influence of Wnt5A signaling on the growth/colonization of commensal bacteria therein.
Wnt5A Signaling Regulates Gut Bacterial Survival and T Cell
Dec 21, 2022 · Here, we demonstrate that in contrast to inhibiting the survival of the established gut pathogen Salmonella enterica, Wnt5A clearly promotes the survival of the common gut commensals Enterococcus faecalis and Lactobacillus rhamnosus within macrophages through a self-perpetuating Wnt5A-actin axis.