Mar 25, 2011 · Ipilimumab "is the first therapy approved by the FDA to clearly demonstrate that patients with metastatic melanoma live longer by taking this treatment." The pivotal study of ipilimumab, known as ...

Jan 23, 2024 · First-line nivolumab plus ipilimumab led to significantly better 2-year PFS in metastatic CRC than chemotherapy as well as pembrolizumab monotherapy. This site is intended for healthcare professionals

Ipilimumab, a novel immunotherapy that relieves T cells of an inhibitory signal, given in combination with a human leukocyte antigen (HLA)-restricted peptide vaccine, or alone, improves survival ...

Oct 28, 2015 · Patients in the ipilimumab group were 25% less likely to experience melanoma recurrence than those in the placebo group (hazard ratio, 0.75; 95% confidence interval, 0.64 - 0.90; P = .0013 ...

Jan 23, 2025 · Long-term data from the CheckMate 067 trial confirmed the superiority of nivolumab combined with ipilimumab, as well as nivolumab monotherapy, compared with ipilimumab alone. “After 6 years, 50% ...

Feb 6, 2025 · Researchers evaluated a neoantigen-targeting personalized cancer vaccine in patients with high-risk, fully resected clear cell RCC with or without ipilimumab. This site is intended for healthcare ...

Aug 21, 2015 · Ipilimumab was the first of the novel immunotherapies launched for melanoma, and so far it is the only one that is an anticytotoxic T-cell lymphocyte-4 (anti-CTLA-4) antibody. It can cause immune ...

Apr 8, 2015 · With ipilimumab already used for the treatment of first-line metastatic melanoma, how strong is the evidence for its use in the adjuvant setting? News & Perspective Drugs & Diseases

Jun 6, 2010 · Ipilimumab is a targeted T-cell antibody, a new class of drugs, said Dr. O'Day. It is directed against an antigen on the surface of T cells. The antigen, cytotoxic T-lymphocyte-associated antigen ...

Ipilimumab (commercial name Yervoy™, Bristol-Myers Squibb, Princeton, NJ) was approved on March 25, 2011 by the US Food and Drug Administration (FDA) for the treatment of advanced melanoma.