In biochemistry, in the biological context of organisms' regulation of gene expression and production of gene products, downregulation is the process by which a cell decreases the production and quantities of its cellular components, such as RNA and proteins, in response to an external stimulus.

The meaning of DOWNREGULATION is the process of reducing or suppressing a response to a stimulus; specifically : reduction in a cellular response to a molecule (as insulin) due to a decrease in the number of receptors on the cell surface.

Down-regulation helps bring your body and mind back to balance. It encourages the release of calming neurotransmitters like GABA and reduces stress hormones like cortisol. Here are some techniques to try: Deep Breathing: Slow, deep breaths activate the relaxation response, slowing your heart rate and reducing tension in your body.

Jun 15, 2023 · The main difference between upregulation and downregulation is that upregulation is the process of increasing cellular components such as proteins and RNA. In contrast, downregulation is the process of decreasing cellular components. Upregulation and downregulation are two processes critical in cellular activities.

Jul 24, 2022 · It is the process that decreases ligand and receptor interactions or reduces the responsiveness of a cell to a stimulus following first exposure.

Down-regulation - when the number of receptors for a neurotransmitter are decreased, typically in response to an increase in the release of that neurotransmitter. Down-regulation can also refer more generally to the decreasing of any cellular component (e.g., protein, RNA).

Development of a refractory or tolerant state consequent on repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent diminution in the number of receptors. Farlex Partner Medical Dictionary © Farlex 2012.

Downregulation refers to the process of decreasing the total number of receptor sites present in cells or tissues, resulting in reduced responsiveness under conditions of prolonged agonist activation. On the other hand, upregulation refers to the gradual increase in …

The term downregulation refers to a distinct process associated with reduced responsiveness of cells or tissues that occurs much more slowly than the process of rapid desensitization. Instead of occurring in seconds or minutes, downregulation is often observed hours or even days after exposure of cells or tissues to ligands.

Down-regulation is typically attributed to increased rate of internalization of bound receptor complexes. Up-regulation may include unmasking of cryptic binding sites (Rui et al., 1987) or result from direct transcriptional upregulation by StatS activation (Galsgaard et al., 1999).