Here we review the epidermal growth factor (EGF), which controls epithelial cells, the precursors of all carcinomas, and the cognate cell surface receptor, called EGFR.

Jan 22, 2025 · EGFR-positive lung cancer represents about 10-15% of lung cancers in the United States and most often appears in the adenocarcinoma subtype of non-small cell lung cancer.

Jan 5, 2023 · Read on to explore the specifics of EGFR lung cancer, a type of non-small cell lung cancer (NSCLC). You’ll also discover how the EGFR mutation affects treatment.

The physiological function of the epidermal growth factor receptor (EGFR) is to regulate epithelial tissue development and homeostasis. In pathological settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a driver of ...

In this EGFR-positive lung cancer video you will learn the answer to these questions: What does EGFR mean? What does having an EGFR biomarker present mean for lung cancer patients? How common is EGFR-positive lung cancer? What does all this mean for treatments for EGFR-positive lung cancer patients?

Jun 1, 2021 · Paracrine loops comprising tumor and stromal cells enable EGFR to fuel invasion across tissue barriers, survival of clusters of circulating tumor cells, as well as colonization of distant organs. We conclude by listing all clinically approved anti-cancer drugs targeting either EGFR or HER2.

Nearly 80% of colorectal tumors overexpress EGFR, and hence EGFR is one of the major targets in colorectal cancer (CRC). Antibodies cetuximab and panitumumab are used as therapeutic agents for metastatic colorectal cancer (mCRC).

Jan 17, 2006 · Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas, and in vivo and in vitro studies have shown that these proteins are able to induce cell transformation.

EGFR signaling regulates in tumor cells the synthesis and secretion of several different angiogenic growth factors, including vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), and basic fibroblast growth factor (bFGF).

Aug 21, 2024 · Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor and a member of the ErbB receptor family. As a significant cancer driver, EGFR undergoes mutations such as gene amplification or overexpression in a wide range of malignant tumors and is closely associated with tumorigenesis.