EGFR translocates from the cell membrane into the mitochondria, and induces mitochondrial fission through inhibition of Mfn1. Therefore, mitochondrial translocation of EGFR promotes ATP production, cell motive ability and mitochondrial redistribution.

A working model of RTK functions in the nucleus. EGFR and ErbB-2 can function in transcriptional regulation. EGFR transactivates cyclin D1, iNOS, and Aurora-A together with the transcriptional factor STAT3 and STAT5. EGFR and E2F1 can stimulate transcription of the B-MYB gene.

Dec 5, 2022 · Epidermal growth factor receptor (EGFR) nuclear translocation correlates with the abnormal proliferation, migration, and anti-apoptosis of tumor cells. Monitoring EGFR nuclear translocation provides insights into the molecular mechanisms underlying cancers.

Dec 25, 2009 · A search for signaling mediators of Tyr(P)-845 revealed that mitochondrial cytochrome c oxidase subunit II (CoxII) binds EGFR in a Tyr(P)-845- and EGF-dependent manner. In cells this association involves translocation of EGFR to the mitochondria, but regulation of this process is ill-defined.

Signaling from activated EGFR occurs at the endosome as well as the cell surface. Endocytosis can have positive and negative effects on signaling and tumorigenesis. EGFR traffic promoted by antineoplastic therapy is important in tumor resistance.

Aug 9, 2001 · When EGFR was fused to the GAL4 DNA-binding domain, we found that the carboxy terminus of EGFR contained a strong transactivation domain. Moreover, the receptor complex bound and activated...

Feb 1, 2011 · EGFR modulates DNA repair after radiation-induced damage through association with the catalytic subunit of DNA protein kinase (DNA-PKcs). We investigated the role of EGFR nuclear import and its association with DNAPKcs on DNA repair after exposure to cisplatin or ionizing radiation (IR).

Dec 25, 2009 · In this study, a multifaceted regulatory mechanism for EGFR translocation to the mitochondria is revealed. Evidence is presented that demonstrates EGFR insertion into the mitochondrial membrane, EGF-induced translocation of c-Src to the mitochondria, and a role for c-Src in EGFR translocation.

Jan 1, 2019 · EGFRvIII's nuclear translocation can significantly promote STAT3 phosphorylation and PKM2 nuclear localization. Finally, we showed that EGFRvIII's nuclear translocation obviously induced the growth of gliomas in an intracranial xenotransplantation experiment.

Apr 22, 2020 · The translocation of EGFR to non-canonical subcellular locations, including the nucleus and mitochondria, represents a major yet underappreciated mechanism of NSCLC development.