Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. Permethrin acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated.

Feb 29, 2024 · Permethrin, a synthetic pyrethroid categorized as a synthetic neurotoxic pyrethroid, is approved for treating scabies and pediculosis capitis. This medication operates within the arthropod nervous system, specifically targeting eggs, lice, and mites.

Permethrin is a medication and an insecticide. [6][7] As a medication, it is used to treat scabies and lice. [8] . It is applied to the skin as a cream or lotion. [6] . As an insecticide, it can be sprayed onto outer clothing or mosquito nets to kill the insects that touch them. [7][9]

Feb 29, 2024 · Permethrin exerts its therapeutic effect by disrupting sodium transport across neuronal membranes in arthropods, inducing depolarization. This mechanism ultimately leads to respiratory paralysis in the affected arthropod, establishing permethrin as a potent agent in managing scabies and pediculosis.

Source: Permethrin is a synthetic chemical used as a pesticide and insect repellent. It is used in agriculture, veterinary health, and medication. Permethrin may be added to lotions intended to treat scabies (a skin infection caused by mites), and to sprays and shampoos used for lice control.

This review summarizes the currently available Environmental Protection Agency–registered IRs, including their origins, mechanisms of action (MOA), side effect profiles, and available formulations.

Permethrin acts on the nerve cell membrane by disrupting the function of voltage-gated sodium channels (VGSCs). This results in delayed repolarization and subsequent paralysis and death of the parasite in all stages ( Lobo and Wheller, 2021 ).

Permethrin 1% generally is considered the treatment of choice and malathion 0.5% is recommended when permethrin resistance is suspected.

Chemical formula: C₂₁H₂₀Cl₂O₃ Molecular mass: 391.288 g/mol PubChem compound: 40326. Permethrin belongs to a group of medicines called pyrethroids which are anti-parasitic agents. Permethrin is rapidly absorbed across the insect cuticle.

Permethrin is the most widely used pyrethroid and acts as an agonist on neuronal voltage-sensitive sodium channels (VSSC) where it causes membrane depolarization, resulting in death of insects (Vais et al., 2001).