May 1, 2023 · Endothelin is a 21-amino acid long peptide that is a vasoconstrictor produced from endothelial cells, vascular smooth muscle cells (VSMC), macrophages, and the renal medulla. …

In this review, we describe the basic functions of endothelin and related molecules, including their receptors and enzymes. Furthermore, we discuss the important role of endothelin in several …

The endothelin signaling pathway depicts the activation of EDNRA to be dependent on either G protein or β-arrestin. The binding of endothelin ligands to EDNRA and EDNRB receptor …

Nov 2, 2023 · Abraham and colleagues review the recent developments and future strategies to therapeutically target the endothelin pathway for a broad spectrum of cardiovascular diseases.

Endothelins are 21- amino acid vasoconstricting peptides produced primarily in the endothelium having a key role in vascular homeostasis.

Endothelin (ET-1) is a 21 amino acid peptide that is produced by the vascular endothelium from a 39 amino acid precursor, big ET-1, through the actions of an endothelin converting enzyme …

Jan 29, 2019 · Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a …

Mar 13, 2019 · In this Review, Dhaun and Webb discuss the biology of the endothelins and endothelin receptors and how these pathways can be therapeutically targeted in …

Sep 11, 2020 · Our attempt to map the endothelin ligand-receptor pathway helps to consolidate the various signaling events that mediate cellular response. The pathway can be a resource …

The endothelin system consists of three potent vasoconstrictive isopeptides, ET-1, ET-2 and ET-3, signaling through two G protein coupled receptors, ETA and ETB, which are linked to …