In organic chemistry, the Swern oxidation, named after Daniel Swern, is a chemical reaction whereby a primary or secondary alcohol (−OH) is oxidized to an aldehyde (−CH=O) or ketone (>C=O) using oxalyl chloride, dimethyl sulfoxide (DMSO) …

The Swern Oxidation of alcohols avoids the use of toxic metals such as chromium, and can be carried out under very mild conditions. This reaction allows the preparation of aldehydes and ketones from primary and secondary alcohols, resp. . Aldehydes do not react further to give carboxylic acids.

Swern Oxidation refers to the organic chemical reaction where oxalyl chloride, an organic base, and dimethyl sulfoxide are employed for the oxidation of primary and secondary alcohols to aldehydes or ketones, respectively.

Mar 31, 2021 · What Is the Swern Oxidation? The Swern oxidation is the oxidation of a primary or secondary alcohol to an aldehyde or a ketone, respectively, by the combination of oxalyl chloride and dimethylsulfoxide followed by triethylamine.

Swern oxidation is a reaction that uses DMSO as an oxidant to oxidize alcohols to aldehydes or ketones in synergistic reaction with (COCl)2 under alkaline conditions and low temperature. Alfa Chemistry introduces the overview, reaction mechanism, and application cases of Swern oxidation reaction.

In Swern oxidation, the primary or secondary alcohols are oxidized to aldehydes or ketones respectively by treating them with dimethyl sulfoxide (DMSO) activated by oxalyl chloride at low temperatures (-78 o C to -60 o C) and then with an organic base like triethyl amine.

Jan 23, 2023 · Below is a standard procedure for the Swern oxidation of an alcohol. Procedure To a solution of oxalyl chloride (5 mmol) and 3 Å MS in CH 2 Cl 2 (1 mL) at -78 °C under N 2 is added dropwise a solution of DMSO (10 mmol) in CH 2 Cl 2 (1 mL).

Feb 28, 2022 · The oxidation of a primary or secondary alcohol to afford, respectively, an aldehyde or a ketone, when treated with oxalyl chloride and dimethyl sulfoxide at very low temperature (below -60 ºC), followed by triethylamine, is known as Swern oxidation.

Swern oxidation is the method that involves the conversion of primary alcohols to an aldehyde, and the secondary alcohol into a ketone, with DiMethyl SulfOxide (DMSO), oxalyl chloride (an organic base), and triethylamine.

Swern oxidation is an organic chemical reaction that is used to oxidize primary or secondary alcohol into an aldehyde or ketone. The reagents used in this reaction are oxalyl chloride, dimethyl sulfoxide (DMSO), and an organic base like triethylamine [1-4] .