Rare Disease Companion (RDC) is a network of news and information websites that supports people living with rare diseases. Through accurate, authentic, and compassionate news coverage, feature-length articles, and patient-friendly educational material, RDC provides insights into living with rare diseases at every point along the patient journey.

About HDFN Companion. Just as many people with rare diseases and disorders such as Hemolytic Disease of the Fetus and Newborn (HDFN) suffer from unmet medical needs, so too do they suffer from unmet informational needs on the web.

3 days ago · In a recent study, researchers surveyed experts in fetal medicine and hematology to develop a consensus-based set of recommendations for managing hemolytic disease of the fetus and newborn (HDFN). Findings were presented at a poster session during the Society for Maternal-Fetal Medicine 2025 Pregnancy Meeting.

Jan 31, 2025 · An infant was recently diagnosed with both HDFN and SMA at the same time. This appears to be the first description in the literature of a presymptomatic infant with SMA who was diagnosed with alloimmune HDFN as well. In this infant, the presence of HDFN was linked to the development of hemolytic ...

Hemolytic disease of the fetus and newborn (HDFN) is a disorder in which a pregnant woman’s immune system attacks her baby’s red blood cells, leading to their destruction and resulting in severe anemia, also known as erythroblastosis fetalis.In severe cases, HDFN can be associated with permanent damage to the baby’s brain or even …

Dec 5, 2024 · The expert panel included over 100 experts from 25 countries. Each one answered different questions regarding critical issues in HDFN management and reached a consensus on optimal techniques for determining fetal blood type, alloantibody titer thresholds, and the use of intravenous immunoglobulin (IVIG).

Blood types and Rh factors. Mismatches that cause HDFN can be between the blood types (A, B and O) and/or Rhesus (Rh) factors, a protein that can be found on the surface of red blood cells.. ABO incompatibility. ABO incompatibility occurs when the blood type of the mother and that of the baby do not match.

Diagnostic tests before birth. The tests that can be used to diagnose HDFN before a baby is born include amniocentesis, ultrasound, and blood tests on the mother or the umbilical cord.. Blood tests. A blood test can be done on blood drawn from a pregnant woman to see whether she has antibodies against the red blood cells of her baby.

Apr 18, 2024 · In the United States, according to a study of HDFN from 1996 to 2010, cases of HDFN correspond with a live birth prevalence of 1695 per 100,000 live births. Among newborns with HDFN, 0.6% of cases were severe. Severe HDFN …

Oct 6, 2023 · In 1911, the ABO blood group system was discovered, and the first ABO testing system was developed. In 1921, a report was issued on inter-ABO incompatibility. 1940s. In 1940, the Rh D antigen was discovered, and indirect and direct agglutination tests were developed from 1945 to 1947.. 1950s. The first measurements of bilirubin in amniotic fluid were performed in 1956, and two years later, the ...