Background Pulmonary hypertension (PH) is a progressive cardiopulmonary condition associated with increased morbidity and ...

Rationale ADAM33 is an asthma susceptibility gene that plays a role in both airway remodelling and susceptibility to allergic airways disease. To study the role of ADAM33 in asthma we have exposed an ...

Asthma attacks (exacerbations) are common, accounting for over 90 000 UK hospital admissions per annum. They kill nearly 1500 people per year in the UK, have significant associated direct and indirect ...

Correspondence to Dr John Field, Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of ...

Department of Child Health, Queen’s University of Belfast, Clinical Institute, Belfast, UK All children experience head colds and many consult their doctor because of associated coughing.1 Cough with ...

Introduction Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are ...

1 Division of Asthma, Allergy and Lung Biology, King's College London, London, UK 2 Department of Palliative Care, Policy and Rehabilitation, King's College London, Cicely Saunders Institute, London, ...

1 Royal Brompton & Harefield Hospitals, Guy’s and St.Thomas’ NHS Foundation Trust, London, UK Since the Guideline, there is deeper understanding of referral characteristics, outcome measures, patient ...

Introduction The PiSZ genotype results in less severe deficiency of alpha-1 antitrypsin (AAT) than PiZZ. Less is known about phenotypic and prognostic features. Methods We studied 699 PiZZ, 126 PiSZ ...

Introduction Although formal patient registries in complex home ventilation have long been recommended 1, recent review found few centres maintain accurate records of activity 2. However, the ability ...

Background CT pulmonary angiography (CTPA) is widely regarded as the gold standard test for suspected pulmonary embolism (PE) and is increasingly used as an all-inclusive diagnostic tool for patients ...

BACKGROUND Varicella is 25 times more likely to be complicated by pneumonia in adults than in children. Data on changes in lung function following pneumonia are limited. This study was undertaken to ...