Houston Astros third baseman Isaac Paredes left Saturday’s game after appearing to injure his right leg running to first base, a potentially calamitous blow for a club already ravaged by injuries.

The Astros currently have 15 players on the injured list, including star slugger Yordan Alvarez, who’s been out since May 2 with a broken hand; All-Star shortstop Jeremy Peña, who’s been out since Ju...