Research reveals why EGFR-targeted cancer therapies often face resistance, leading to ongoing studies on combination treatments.

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR ...

The EGFR pathway is known to be critical in several types of cancer, but this is the first association of an EGFR gene alteration with this tumor.

In this study, we aimed at testing the hypothesis that ACh increases the proliferation rate of tenocytes through mAChR stimulation, as well as investigating whether this mechanism is mediated by the ...

The researchers found that FBXW7 mutations lead to increased signaling activity of the EGFR pathway and a decreased response to anti-EGFR treatment.

EGFR TKIs have significantly changed the treatment landscape of NSCLC for patients with EGFR mutations by targeting the critical tumorigenic EGFR pathway. However, the clinical efficacy of these ...

This study explored the role of EGF/EGFR signaling in regulating oral keratinocyte motility and proliferation. EGF/EGFR and its downstream Src/PI3K/Akt/mTOR pathway were found to be key regulators ...

Conclusions: Patterns in gene and pathway expression were observed in our cohort of patients with EGFR -mutated NSCLC. Analyzing RNA sequencing pathways showed differential up and down regulation of ...

Beveridge, now with Avalere Health, addressed the importance of clinical pathways in selecting therapies in non-small cell lung cancer (NSCLC) and the emergence of options for EGFR Exon 20 ...

Edward Arrowsmith, MD, MPH, medical director for clinical pathways for OneOncology, discussed treatment challenges in EGFR Exon 20 insertion+ non-small cell lung cancer (NSCLC) and best practices ...

Furthermore, activation of the EGFR pathway by administrating epidermal growth factor (EGF) to the parental lines TPC-1 and FRO before they acquired resistance induced a decrease in lenvatinib ...

While high expression of epidermal growth factor receptor (EGFR) has been considered an adverse prognostic sign in some types of breast cancer, a new study found that it’s more complex than once ...