CKD-702, which is currently in phase 1 trials, effectively neutralizes, internalizes and degrades both EGFR and MET receptors, disrupting downstream oncogenic signaling. Promising preclinical ...

The study delves into the well-established role of EGFR-mediated signaling in CRC progression ... focusing on targeting downstream molecules within the RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways.

Figure 1: Key signaling pathways and targeted factors ... The MAPK pathway, initiated by RTKs like EGFR and HER2, activates downstream effectors such as RAS, RAF, MEK, and ERK1/2, driving cell ...

From April 25 to 30, 2025, the American Association for Cancer Research (AACR) Annual Meeting will take place in Chicago. CStone will showcase its latest preclinical studies on five internally ...

The EGFR signaling pathway is one of the key pathways that regulate growth, survival, proliferation, and differentiation of cells. B-Raf is a protein encoded by the BRAF gene and is a downstream ...