In football, defense keeps the opposing team in check. A similar strategy is at play inside our cells. Negative feedback ...

Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem ...

Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central ...

A Growing Double BurdenThe rising prevalence of prediabetes and chronic kidney disease (CKD) in India reflects an ...

A Cancer Gene Therapy study reveals that MEOX2 promotes lung cancer progression while SMARCB1 acts as a tumor suppressor, influencing EGFR expression and response to tyrosine kinase inhibitors.

Creative Biolabs recently updated its antibody chip platform, expanding product arrays for phosphorylation signaling and cytokine detection. SHIRLEY, NY, UNITED STATES, May 27, 2025 /EINPresswire.com/ ...

CS2011 is a bispecific antibody with high binding affinity to both EGFR and HER3. It effectively blocks downstream signaling of both targets, thereby inhibiting tumor growth on EGFR/HER3 positive ...

During a live event, Xiuning Le, MD, PhD, discussed updated intracranial efficacy, overall survival, and safety of amivantamab plus lazertinib in patients with EGFR-mutated non–small cell lung cancer.

The inhibitors bind to critical domains of EGFR, RAF1, or STAT3, preventing their activation. This blockade disrupts downstream signaling pathways, leading to tumor cell death and regression. As such, ...

Expression analysis also implicates EGF signaling as being altered downstream of Ezrin loss, and the authors demonstrate that Ezrin promotes relocalization of EGFR from the plasma membrane to ...

G proteins undergo a GDP-GTP exchange on the α subunit, leading to the dissociation of the α and βγ subunits and subsequent activation of downstream signaling effectors ... diacylglycerol; EGFR, ...

Ephrin A1 directly interacts with EGFR and induces EGFR dimerization, phosphorylation and activation of downstream signaling. Ephrin A1-induced EMT can be rescued by EGFR signaling inhibitors or ...