The cold sore-causing Herpes Simplex Virus (HSV-1) hijacks human cells and reconfigures its DNA within just an hour after ...

Scientists in Spain and China discovered that HSV-1 begins rewriting the architecture of human genes just one hour after ...

Researchers from the University of Maine and Bigelow Laboratory for Ocean Sciences have demonstrated a new approach to ...

Ningbo Newbay Medical Technology Co. Ltd. has identified helicase bicycle amide derivatives acting as DNA polymerase θ (POLθ, POLQ) inhibitors reported to be useful for the treatment of cancer.

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

The growing incidence of infectious diseases, cancer, and chronic illnesses has substantially increased the demand for ...

Six new 5-position modified dUTP derivatives connected by a unique amide linkage were synthesized and tested for compatibility with the enzymatic steps of in vitro selection. Six commercially ...

The promoter of the human imprinted gene MEST is differentially methylated with respect to the parent of origin and contains several non B-DNA motifs that are capable of forming G-quadruplexes. These ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

In the world of viral research, uncovering a virus’s weaknesses is often a painstaking process that requires years of ...

Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...