In a new study, researchers in the U.S. have created a workaround called Magnetic Isolation and Concentration cryo-electron ...

This deep learning strategy allows to robustly detect these intricate particles, a crucial step in achieving high-resolution reconstructions in cryo-EM studies. To encourage collaborative advancements ...

Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, United States, and National Center for Macromolecular Imaging, ...

A new method uses magnetic beads to hold molecules in place, keeping the sample intact and reducing sample loss by a ...

and the magnetic beads to the grid. With the particles securely in place, blotting could then be done safely, with far less sample loss. "In traditional cryo-EM, the target molecules just float ...

and the magnetic beads to the grid. With the particles securely in place, blotting could then be done safely, with far less sample loss. “In traditional cryo-EM, the target molecules just float ...

We thank Advanced Center for Electron Microscopy at Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), for providing technical support and assistance during data collection. This ...

Cryo-Electron Tomography (cryo-ET), i.e. the application of ... The tissue was placed on the back of an EM-grid, i.e. on the reverse side of a continuous support film and squeezed into the ...