principally due to their role in regulating the WNT signaling pathway. Aberrant WNT/β-catenin signaling has been implicated ...

Photodynamic therapy (PDT) resistance limits treatment efficacy in oral leukoplakia (OLK). This study identifies p-NRF2 as a ...

Acute myelogenous leukemia, or AML, remains one of the most aggressive blood cancers. Each year, around 44,000 people in the ...

Envision this possible future clinical scenario: a breast cancer patient and her physicians are deciding on the best possible ...

Tarpon Springs, Florida Wednesday, June 4, 2025, 12:00 Hrs [IST] ...

3 The phase 1 dose-escalation portion of the study examined ST316 at various dose levels in patients with select advanced solid tumors that are known to harbor abnormalities of the Wnt/β-catenin ...

β-Catenin can then displace the inhibitory TLE/Groucho complexes, enabling TCF/LEF to transcribe the target genes. PP2A can also enhance Wnt signaling by dephosphorylating β-catenin, APC ...

While LGK974 was effective in reducing the vascular expression of the Wnt/β-catenin/TCF signaling target gene Axin2, it did not significantly curtail the progressive enlargement of the aortic ...

USP7 protects β-catenin in cells, leading to its accumulation when the APC gene is mutated. USP7 inhibition/depletion inhibits Wnt signaling in APC mutant colorectal cancers by restoring β-catenin ...

The non-canonical pathway or β-catenin-independent pathway is further divided into the Planar Cell Polarity pathway and the Wnt/Ca2+ pathway. Wnt signalling via Frizzled receptors directs ...

The article: The time-resolved genomic impact of Wnt/β-catenin signaling, Pierfrancesco Pagella, Simon Söderholm, Anna Nordin, Gianluca Zambanini, Valeria Ghezzi, Amaia Jauregi-Miguel and ...