The canonical Wnt signaling pathway. The left panel (A ... In the absence of Wnt signaling (B), the destruction complex breaks down β-catenin and inhibits gene transcription.

Photodynamic therapy (PDT) resistance limits treatment efficacy in oral leukoplakia (OLK). This study identifies p-NRF2 as a ...

It arises from chronic liver diseases, including hepatitis B or C infections ... the crucial role of the Wnt signaling pathway, especially its β-catenin axis, in HCC. This pathway regulates ...

It arises from chronic liver diseases, including hepatitis B or C infections ... the crucial role of the Wnt signaling pathway, especially its β-catenin axis, in HCC. This pathway regulates ...

A Wnt/β-catenin pathway agonist under development by Surrozen appears to be effective against idiopathic pulmonary fibrosis (IPF) in mouse models, according to new data. The results, published ...

Panel B shows that if Wnt signaling is active, β-catenin degradation is reduced. SFRPs antagonize the Wnt-signaling pathway by binding to either Wnt or frizzled receptor, thereby affecting ...

In conclusion, the study underscores the significant role of the Wnt/β-catenin pathway in human and experimental AAA, but the therapeutic interventions tested, LGK974 and PRI-724, showed limited ...

Through both in vitro and in vivo experiments, the research team examined how LGK974 affects bone formation and the Wnt/β-catenin signaling pathway. The results were striking: LGK974 inhibited ...