Weizmann Institute of Science-led researchers have unveiled a computational workflow that crafts enzymes exhibiting catalytic ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental ...

Although the mutated enzyme can still assemble correctly, its dynamic changes tend to hinder substrate access to the cavity ...

Chemical trapping strategies have recently emerged as powerful approaches for investigating the structural dynamics of E3 ligase-catalyzed substrate ubiquitination. However, current ...

Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of ...

Heterologous expression and precursor feeding experiments revealed an unprecedented tailoring pathway in which anthranilate is modified to yield 5-methoxyanthranilate (5-MA), a substrate for ...