Antibiotics that target bacterial cell wall synthesis: β-Lactams (usually given with a β-Lactamase inhibitors to prevent the bacteria from inactivating the beta-lactam ring of the antibiotic ...

Infants of mothers treated in the first trimester with TMP-SMX appeared to have a higher risk for any malformation than those ...

A study of more than 70,000 US pregnancies suggests a commonly used antibiotic for urinary tract infections (UTIs) may be ...

That beta-lactam ring is the key for the bacteria to defeat the antibiotic. Bacterial cells contain proteins involved in forming the cell walls that penicillin can bind to.

Beta-lactam antibiotics are time-dependent, meaning they are most effective when their serum concentration is above the target pathogen's minimum inhibitory concentration, explained Rhee and ...

Prolonged infusion of beta-lactam antibiotics for sepsis or septic shock tended to improve mortality compared with conventional intermittent infusion in the BLING III trial, and a meta-analysis ...

This presentation explores the pharmacokinetics (PK) and pharmacodynamics (PD) of β-lactam antibiotic dosing, particularly in ICU patients. To optimize PK/PD targets, two strategies are possible and ...

Scientists have discovered that the enzyme BbLDH is crucial for the survival and infectivity of the Lyme disease bacterium Borrelia burgdorferi. This finding opens the door to targeted treatments for ...

Residents at long-term care communities who had a documented penicillin allergy were 95% less likely to receive beta-lactam antibiotics — the kind often preferred for many infections ...

As strains of pathogens resistant to frontline antibiotics become more common worldwide, clinicians are more often turning to combination treatments that degrade this resistance as a first treatment ...