This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

Individual mutation of R22 or the hydrophobic motif impaired Roq1-Ubr1 binding, and the combined mutation of both determinants rendered the interaction undetectable (Fig. 4C). These results provide ...