An obscure group of phages offers insights into elements of microbial warfare—and blueprints for new antibiotics.

Multidisciplinary AI- and physics-driven modeling of the viral fusion process has enabled the discovery of an orally available drug inhibiting infection with multiple coronaviruses.

About 30% of all respiratory tract infections are caused by coronaviruses, leading to widespread illnesses and, in some cases ...

Scientists have discovered a unique class of small antibodies that are strongly protective against a wide range of SARS ...

Ebola viruses (EBOVs) assemble into filamentous virions, whose shape and stability are determined by the matrix viral protein 40 (VP40). Virus entry into host cells occurs via membrane fusion in late ...

Diabetes, heart disease, high blood pressure, cancer, and viral infections also depend highly on membrane fusion and could eventually be treated by intervening in this process, Dr. Rizo-Rey said.

Membrane fusion is a fundamental process that is exploited by enveloped viruses to enter host cells. In the case of the influenza virus, fusion is facilitated by the trimeric viral hemagglutinin ...

ACE-2 is activated through proteolytic cleavage and drives fusion between the cellular membrane and the viral envelope. Circumstantial evidence from studies suggests that ACE-2 may not just serve ...

Cell-cell fusion is initiated by the viral arginine motif and its interaction with host cell membrane, Ca2+, TMEM16F, PS, and the cytoskeletal proteins (Whitlock and Chernomordik, 2021) (Figure 1). In ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is critical for membrane fusion and eventual viral infection. Enveloped viruses use highly specific protein machinery ...