for many viruses the fusion event occurs at the plasma membrane of the target cell and, in these cases, extra proteins in the viral envelope might be involved in assisting the fusion process.

Viral membrane fusion to the host endosomal membrane is an essential step to successful infection. The rate and efficiency at which fusion occurs is determined by multiple independent variables and is ...

ACE-2 is activated through proteolytic cleavage and drives fusion between the cellular membrane and the viral envelope. Circumstantial evidence from studies suggests that ACE-2 may not just serve ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is critical for membrane fusion and eventual viral infection. Enveloped viruses use highly specific protein machinery ...

To study how HA can facilitate the fusion between viral membrane and host endosome membrane, Wong and colleagues let HA interacted with exosomes, a lipid bilayer cargo that mimics endosome.

We've developed a method whereby the different stages of fusion can be detected by the release of different fluorescent tags. We inserted blue dye into the viral membrane so that at the moment fusion ...

Despite its isolation three decades ago, Ebola virus continues to cause periodic outbreaks of severe hemorrhagic fever in humans, and the closely related Marburg virus is responsible for a recent ...

Diabetes, heart disease, high blood pressure, cancer, and viral infections also depend highly on membrane fusion and could eventually be treated by intervening in this process, Dr. Rizo-Rey said.

Researchers who study membrane-driven processes such as synaptic communication, sperm-egg fusion, and viral infection have focused on the ways that proteins can regulate lipids to control membrane ...

and lead to treatments that prevent cell-to-cell fusion between cancer cells and non-cancer cells. When two cells combine during fertilization, or a membrane-bound vesicle fuses during viral entry ...