However, the mechanisms by which tyrosine kinase potentiates NMDA-receptor function are unknown. In addition, NR2B subunits are phosphorylated by one of the Src family of tyrosine kinases 8 ...

Receptor tyrosine kinases (RTKs ... for RTKs in part due to an emphasis on the discovery of ATP-competitive tyrosine kinase domain inhibitors. Biased ligands hold therapeutic promise due to ...

Herbst, RS, Maddox, A-M, Rothenberg, ML, et al. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung ...

Synthetic biologists from Rice University and Princeton University have demonstrated "live reporter" technology that can reveal the workings of networks of signaling proteins in living cells with ...

One of the proteins, called epidermal growth factor receptor (EGFR), belonged to ... the new generation of anti-cancer drugs called Tyrosine Kinase Inhibitors (TKIs). Yet these are some of the ...

Because the signaling pathways activated by several tyrosine kinase receptors have been shown to be involved in lung fibrosis, it has been suggested that the inhibition of these receptors may slow ...

We are also actively investigating the regulation of Syk tyrosine kinase binding to membrane immune receptors and other signaling proteins. Syk recognizes doubly phosphorylated regions of the receptor ...

hepatocyte growth factor receptor, and AXL tyrosine kinase receptor inhibitor cabozantinib in combination with atezolizumab improved progression-free survival versus sorafenib, but at this time ...

Lenvatinib was associated with the most significant probability of producing all grades of cardiovascular injury and hypertension. Vascular endothelial growth factor receptor tyrosine kinase ...