Gum disease caused by the bacteria Porphyromonas gingivalis is linked to worse multiple sclerosis (MS) in a mouse model of ...

Established in 2017, the International Player Pathway program provides players born outside the United States greater opportunity to seek an NFL roster spot. Though he originally agreed to a sign ...

These TLR adaptors, myeloid differentiation protein 88 (MyD88) and TIR domain-containing adaptor inducing interferon β (TRIF) facilitate distinct inflammatory signaling pathways. In an earlier study, ...

TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these ...

However, the regulation of DPP4 expression is not well understood. In the current study, we identified that CD36/TLR4/TRIF inflammatory pathways are responsible for the upregulation of ...

This finding suggests that a “TRIF-dependent innate immune pathway determines disease progression,” the researchers wrote. Further experiments also showed that TRIF deficiency led to lower numbers of ...

"We found that ablation of TRIF significantly shortens survival time of ALS mice," says Okiru Komine, first author of the study. "While MyD88 is also a crucial adaptor for most TLR signaling pathways, ...

"These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice ...

"These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice ...

"These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice ...