The group emphasized balancing survival benefits with toxicity and selecting therapies with distinct mechanisms of action instead of rechallenging patients with similar therapies. What are the goals ...

Trastuzumab deruxtecan-THP was associated with a statistically significant and clinically meaningful improvement in pathologic complete response rate vs standard of care. The DESTINY-Breast11 ...

Another possible mechanism of action is the preferential exertion of antibody- dependent cellular cytotoxicity on HER2-overexpressing cancer cells. [62] Trastuzumab contains an immunoglobulin G1 ...

Please discuss the class and complete drug profile of amyloid-targeting therapies for Alzheimer disease, including their mechanisms of action, efficacy, and safety profiles. Stay ahead of policy ...

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

In a review published in the Journal of Dermatologic Science and Cosmetic Technology, two Chinese researchers looked into the mechanism of action of preservatives in cosmetics. Co-author Zhenyu ...

In breast cancer, HER2-targeted therapy with trastuzumab has gained significant attention, owing to the dramatic response observed in a subset of HER2-positive patients. The mechanisms of action ...

“We are encouraged by the results of this AD trial exploring how targeting the disease from different angles with different mechanisms of action impacts disease markers,” said Kreesten ...

A research team now describes a new mechanism of action that kills cancer cells through ferroptosis. In a first, a Bochum-based team has produced a substance capable of sending cancer cells into ...

Among these medications, trastuzumab stands as a cornerstone in the management ... Generally, these ADCs are well-tolerated, with toxic effects consistent with the known mechanism of action of the ...