In the past two decades, many algorithms have been proposed to predict the signal peptide domain and the transmembrane domain of membrane proteins. The signal peptide domain and the transmembrane ...

Recently, I have made some attempts to model transmembrane proteins with AlphaFold3 in the server, successfully adding up to 200 oleic acid molecules. Due to the purpose of my current research, I aim ...

Neurotrophin (NT) receptor signaling regulates neuronal survival, axonal and dendritic network maintenance, differentiation, and synaptic plasticity. Signaling is initiated by binding of NT to the ...

Human signal peptide peptidase may represent another family of aspartic proteases that promote intramembrane.

Cell Biology C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin ...

We also show that the secretory trafficking of tagged emerin depends on its unusually hydrophobic transmembrane domain (TMD). In isolation, the TMDs of both emerin and the related tail-anchored ...

Designing peptide therapeutics requires precise peptide docking, which remains a challenge. We assessed the ESMFold language model, originally designed for protein structure prediction, for its ...

Peptide therapy enhances targeted medicine, utilizing specific peptides for effective treatment of cancer, metabolic disorders, and neurodegenerative diseases.

STEAP1 (Six-transmembrane epithelial antigen of the prostate 1), originally identified in prostate cancer, is a member of the STEAP protein family.