MTX disrupts these processes by impeding DHFR, causing intracellular depletion of THF, particularly in rapidly dividing cells. Beyond DHFR inhibition, MTX and the polyglutamate forms impede de novo ...

Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...

The Grievance Redress Service (GRS) is an avenue for individuals and communities to submit complaints directly to the World Bank if they believe that a World Bank-supported project has or is likely to ...

Escherichia coli dihydrofolate reductase (DHFR) has several flexible loops surrounding the active site that play a functional role in substrate and cofactor binding and in catalysis. We have used ...

Reactions involving the transfer of a phosphoryl (−PO32–) group are fundamental to cellular metabolism. These reactions are catalyzed by enzymes, often large and complex, belonging to the ...

Similarly, the de novo synthesis of pyrimidine ends with the production of UMP, from which other pyrimidine nucleotides are converted. Temporal metabolome profiles clearly revealed that out of 17 ...

Abstract Copious expression of protein arginine methyltransferase 1 (PRMT1) is associated with poor survival in many types of cancers, including acute myeloid leukemia. We observed that a specific ...