Newborn screening programs have expanded to include molecular-based assays as first-tier tests and the success of these assays depends on the quality and yield of DNA extracted from neonatal dried ...

The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

DNA ‘barcodes’ shed light on how the blood ages - The discovery could help prevent diseases years before symptoms appear, as ...

We discovered that DNA-methylation patterns can be used as native-lineage-tracing barcodes. We explored DNA-methylation patterns in single cells using scTAM-seq 1. Unlike most methods, scTAM-seq ...

Researchers analyzed DNA material in fecal samples from wild carnivores in Southern Africa to identify a specific genetic marker, called a “mini-barcode,” that can be used to determine the ...

However, it has shown limitations in terms of high costs and inefficiencies. The productivity and accuracy of DNA methylation detection rely critically on the optimization of methodologies and the ...

The final products of replication are supercoiled Circular Monomers (scCMs) that arise from compensatory negative supercoiling of the template DNA when the reaction is stopped and the chromatinized ...

Corrections are only available during system training. Developing the system, nearly 850,000 N-labels are obtained from Barcode of Life Data systems, the premier database of genetic markers called DNA ...

The authors advance this technique by integrating peptide ligation technology and nanobody-based antibody mimetics - cost-effective and scalable alternatives to conventional antibodies - into a ...

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