Dedicated April 23, 2003, at the Research Triangle Institute in Research Triangle Park, North Carolina. Commemorative Booklet (PDF) Monroe Wall, Mansukh Wani and colleagues at the Natural Products ...

Taxol sales grew 40% a year since 1993, ... researchers systematically manipulated the drug's chemical arms and legs to find a structure that might bind better to both normal and mutated ...

Taxol, one of the most widely used anticancer drugs, interferes with the splitting of cells, ... This comparison clearly showed the effect Taxol has on microtubule structure. ### ...

To find these details, Nogales, an expert in electron microscopy and image analysis and a leading authority on the structure and dynamics of microtubules, employed cryo-EM, in which protein ...

But, the nightmare is just beginning. Next, the chemical structure must be elucidated (solved), which is done by use of a powerful arsenal of analytical instruments. This process can take years ...

Taxol is a chemotherapy drug used in the treatment of specific human cancers. ... one of which is to act like a type of skeleton structure that helps give cells their shape. When cells replicate, ...

While most information to date about the structure of tubulin inside the microtubule has come from the study of artificial, flat sheets of aligned strips of tubulin, Nogales was able to probe ...

Paclitaxel is a prominent natural compound used for the treatment of refractory cancers. ... in pure form took several years, the chemical structure was finally published in 1971.

While Taxol's side effects are many, Dr. Russell said its ability to save lives makes it revolutionary. "If you think about the 230,000 cases every year of breast cancer in our country.