Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central ...

How do breast cancer cells bypass the blood-brain barrier (BBB) to colonize the brain? This study uncovers a ...

The FDA approved taletrectinib for ROS1-positive NSCLC. The agent shows efficacy for both new and pretreated cases, including ...

More than 40 million people worldwide are living with HIV-1, which continues to be a major global health challenge due to its ...

Figure 1 Toll-like receptors (TLRs) and their signaling pathways. TLRs are situated either on the cell surface (such as TLR1/2, TLR2/6, TLR4, TLR5) or intracellularly (like TLR3, TLR7/8, TLR9). With ...

Signaling pathways downstream of TLRs are tightly regulated for preventing collateral damage and loss of tolerance toward commensals. To trigger effective intracellular signaling, these receptors ...