Immunotherapy is gaining traction as a prominent approach to cancer treatment. These therapies encompass the use of Chimeric ...

Gut bacteria produce metabolites that influence drug metabolism and affect immune cell function, potentially enhancing or ...

CAR T cell immunotherapy, which uses a patient's own modified immune cells to find and destroy cancer cells, can produce ...

T cell receptors (TCRs) orchestrate cellular immunity by recognizing ... 4.9 Generation and maintenance of TCR-expressing Jurkats and T2 antigen presenting cells CD8+ Jurkat 76 and T2 cell lines were ...

The culprit: a drop in levels of nicotinamide adenine dinucleotide (NAD), a molecule essential for cellular energy and metabolism of mitochondria. "CAR-T cells from older individuals are ...

CAR-T cells are, in essence, T-lymphocytes equipped with a next-generation membrane receptor: a structure specifically designed to recognize and attack tumor cells with a precision and sensitivity ...

Electron microscopy image of young naïve CD8+ T cells ... these immune cells and reviving their cancer-fighting abilities in lab tests. This reinforces the idea that aging significantly alters immune ...

Dual-targeted CD19/CD22 CAR T and CD19/CD22 CAR T-cell therapy are currently being evaluated in clinical trials, and the extent of improvement using CD19 in combination with dual-targeted therapy has ...