Morphine is a potent opioid medicine utilized for the management of moderate to severe pain, particularly in palliative care, ...

By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory ...

Special Issue Published as part of ACS Medicinal Chemistry Letters special issue “Academic and Industrial Collaborations in Drug Discovery”. Academic–industry collaborations are broadly beneficial ...

Irreversible inhibition as a therapeutic modality has come of age over the previous decade. With minimal theoretical guidance for the design of an irreversible modulator, empirical optimization ...