Studying the production mechanisms, internal structure, and de-excitation properties of these excited-state atoms provides insights into quantum electrodynamics and quantum many-body interactions ...

“That year, two landmark papers showed that mutations in IGHV [immunoglobulin heavy chain variable region] genes were a favorable prognostic marker, supporting a genetic model.

Scientists have designed a way to 'cloak' proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.

ImmuMab Heavy ® mice are able to produce fully human antibodies, consisting solely of heavy chains, without the presence of light chains. These mice possess over 120 human immunoglobulin heavy-chain V ...

The variable domain of a BCR is composed of a heavy chain and a light chain. Each of the chains in the antibody has three hypervariable regions known as the complementarity-determining regions (CDRs), ...

RenNano™ mouse has modified heavy chain constant regions to generate functional HCAbs. RenMice™ can generate robust immune response and produce fully human antibodies with great diversity ...

Study: Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies. Image Credit: ktsdesign/Shutterstock Background The human immunoglobulin (Ig) heavy ...

Study findings The results suggested 82% light chain coherence in different origin memory B-cells with the same heavy chain genes for the V region and a CDRH2 amino acid identity of 100%.

We have therefore investigated immunoglobulin heavy chain repertoires from memory B cells, plasmablasts, and plasma cells from peripheral blood collected from generally healthy volunteers at three ...

Reference Ursule-Dufait C, Bengoufa D, Theodorou I, Villesuzanne C, Arnulf B. Heavy chain/light chain assay is a useful biomarker for diagnosis and management of patients with cold agglutinin disease.

Here, we demonstrate that the marginal zone B and B-1 cell-specific protein (MZB1) interacts with IgA through the α-heavy-chain tailpiece dependent on the penultimate cysteine residue and prevents the ...