Thus, the major serum immunoglobulin is tetrameric IgM ... presumably due to an extra cysteine near the C-terminus of the heavy chain. The typical A/B ratio is approximately 40/60. Anion exchange ...

An antibody molecule consists of two heavy chains (approximately ... monomeric structure and high diffusibility, IgG is the most abundant type of immunoglobulin in the extracellular fluid.

Immunoglobulin loci-transgenic animals are widely used in ... to increase the depth of our repertoire sampling by over 200-fold (from on average 218.4 heavy chain clonotypes per sample to an average ...

We have therefore investigated immunoglobulin heavy chain repertoires from memory B cells ... we are able to describe the structure, distinctive features, clonal relations, isotype distribution and ...

Only one functional bispecific antibody exists due to the random assembly of two different heavy and light ... which is required for the “immunoglobulin fold” structure, is absent in expressed ...

Dawning with growing interest in RNA is the insight that the stability, structure ... with the genomic site that encodes the heavy chain of antibodies (immunoglobulin H, IgH).

An antibody is sometimes called an immunoglobulin ... arranged in a light-heavy-heavy-light structure. The light chains weigh approximately 25 kilodaltons (kDa), and the heavy chains about ...

The specificity-defining variable domains of human immunoglobulin heavy chains are encoded by genes [IGHV (immunoglobulin ... It is hypothesized that C92 compromises the structure or stability of the ...

The structural templates for the light and heavy chains can be identified ... of each loop is grafted from the immunoglobulin with equivalent canonical structure and the best BLOSUM62 (blocks ...