The structural diversity and good biocompatibility of cyclic peptides have led to their emergence as potential therapeutic agents. Existing cyclic peptide design methods, whether traditional or ...

By optimizing the peptide's size and side chain structure, they identified DC646 as the most potent FXR antagonist, with an inhibition rate exceeding 70%.

By optimizing the peptide's size and side chain structure, they identified DC646 as the most potent FXR antagonist, with an inhibition rate exceeding 70%.

Cyclic citrullinated peptides are circular proteins that contain citrulline. When inflammation is present, the body converts the amino acid arginine to the amino acid citrulline. In RA, the joints ...

Cyclic peptides, known for their unique ring-like structures, show considerable promise in therapeutic applications. Experimentally determining their permeability is time-consuming and labor-intensive ...

That cyclic shape provides a greater surface area for peptides to disrupt the deleterious protein-to-protein interactions that drive diseases, and the cyclic structure’s stability helps the ...

"Breakthrough in creating cyclic peptide opens the way for new antibiotics." ScienceDaily. ScienceDaily, 10 June 2024. <www.sciencedaily.com / releases / 2024 / 06 / 240610171005.htm>.

News Release 10-Jun-2024 Breakthrough in creating cyclic peptide opens the way for new antibiotics Peer-Reviewed Publication King's College London ...

The protein uses copper and oxygen to form cyclic peptides. We can investigate how this chemistry occurs more thoroughly now that we know what the protein structure looks like.