Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper cell division. During ...

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the ...

"This new structure provides clues about which important ... to act as a DNA replication gatekeeper and to the survival of cancer cells. "This work and our structure-activity knowledge gained ...

Cancer cells seldom start off stealthy ... named after the enigmatic Sphinx of Greek lore because of their puzzling structure and function. Two centuries later, sphingolipids are less of a ...

Published in Nature Communications, the article explores the influence the mechanical stiffening of the tumor cell's environment may have on the structure and function of the nucleus. "Cancer has ...

This three-protein assembly, called the SHOC2-MRAS-PP1C ("SMP") complex, regulates the RAS signaling pathway and helps cancer cells with RAS mutations survive. The high-resolution structure of ...

Cancer cells have an insatiable appetite for energy ... Scientists at Sanford Burnham Prebys and the Mayo Clinic published findings in Structure that provide a detailed structure of human uMtCK ...

Left: the three-dimensional structure of a PNMA2 complex ... “This protein normally is only expressed in the brain, in neurons,” Xu says, “but some cancer cells can express it, which can trigger an ...

In our previous work, we found that T cells become dysfunctional with dramatically altered genetic structure within five days of encountering cancer cells in mice. We had originally decided to ...

Blocking the carrier could then starve these cancer cells of the energy they need to ... "This creates new opportunities for structure-based drug design in order to develop better, more targeted ...