Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...

In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish ...

The non-descript, pill-shaped cell is why we understand fundamental life processes (think DNA replication and transcription).

Researchers have successfully disrupted the hepatitis B virus's ability to infect human liver cells in the laboratory using a ...

Researchers say if their results are confirmed through further study they are optimistic the approach could be used to treat chronic infections for the first time.

"We were delighted to discover not only important details about the mechanisms of HBV gene regulation, but also a promising ...

In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells ...

In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, research led by Memorial Sloan Kettering Cancer Center ...

These mechanisms include sequential steps that translate the genetic ... Once bound, RNA polymerase unwinds a short stretch of DNA, forming a transcription bubble, and begins synthesizing the ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Next, using next-generation sequencing methods, the investigators sequenced all the DNA bound by each transcription factor ... dataset represents an important step towards understanding how ...