Early trials found that both garadacimab and sebetralstat were safe when used in patients living with hereditary angioedema, ...

Blood clotting is a complex, tightly regulated process involving numerous molecular steps and myriad biomolecules to carry ...

A team led by the University of Sydney has identified red blood cell rupture at dying endothelial sites as a primary driver ...

A new statement from leading heart and blood vessel experts in Europe is providing clinical guidance for treatments to ...

According to the traditional clotting pathway, when a blood vessel is injured, tiny cell fragments called platelets quickly stick to the damaged site and one another, forming a temporary plug.

Researchers at the Indian Institute of Science (IISc) have developed an artificial metal-based nanozyme that can potentially be used to clamp down on abnormal blood clotting caused by conditions ...

The blood is exposed to collagen in the activated vascular endothelium, initiating coagulation. Platelets respond to the site of injury and become activated, releasing substances such as growth ...

Production begins when tissue factor in the extrinsic coagulation pathway is exposed in a blood vessel. Tissue factor then binds factor VIIa (Figure 1), and the complex of factor VIIa and tissue ...

In this article, we provide a brief review of selected key pathways in which links between coagulation and inflammation have been reported. We begin with the central player and common trigger, tissue ...

Updated results from the phase 3 XTEND-1 trial were presented at ISTH, once again comparing the therapy to patients' previous treatment with clotting factor replacement.