More information: Highly potent quinoxalinediones inhibit a-hemolysin and ameliorate Staphylococcus aureus lung infections, Cell Host & Microbe (2025). DOI: 10.1016/j.chom.2025.03.006 . www.cell ...

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution. Cell Reports , 2020; 33 (2): 108247 DOI: 10.1016/j.celrep ...

Article Title. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections ...

Pneumonia caused by the bacterium Staphylococcus aureus is one of the most dangerous ... The new research approach is aimed at the targeted inhibition of the key virulence factor α-hemolysin.

The research is published in the paper, “Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution,” in Cell Reports ...

This downregulation resulted in decreased ability of the bacteria to adhere to host cells, and reduced S. aureus toxin-mediated hemolysis and thrombolysis of host cells.

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that does not respond to several antibiotics. Depending on which part of the body it affects, symptoms range from skin infections ...

Pneumonia caused by the bacterium Staphylococcus aureus is one of the most dangerous ... The new research approach is aimed at the targeted inhibition of the key virulence factor α-hemolysin.

Reference: Shekhar A, Di Lucrezia R, Jerye K, et al. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections. Cell Host Microbe. doi: ...

04/01/2025 10:17 New agent inhibits Staphylococcus aureus toxin – hope for pneumonia patients Dr. Andreas Fischer Presse und Kommunikation Helmholtz-Zentrum für Infektionsforschung. Helmholtz ...