New research provides fresh and unexpected insight into the structure of sodium channels and, specifically, one of its components -- ²-subunit molecules -- which are responsible for 'fine-tuning ...

Northwestern Medicine scientists have mapped the complete structure of a voltage-gated sodium channel, proteins in the membrane of cells that play an important role in many diseases. The findings ...

Thus, this structure is expected to transform our current ideas of gating in homologues of sodium channels. Thrombin cleavage took place at 18 °C for 36 h at 20 units per 4 mg of protein.

Their latest findings appear Dec. 19 in Cell in the paper, "Structure of the Cardiac Sodium Channel." The senior authors are William Catterall and Ning Zheng, both UW School of Medicine professors ...

New Cambridge research provides fresh and unexpected insight into the structure of sodium channels and, specifically, one of its components - β-subunit molecules - which are responsible for 'fine ...