Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

Exploring the efficacy and mechanism of action of combined pan-Raf and MEK inhibition in halting the growth of non-V600 BRAF mutated tumors.. If you have the appropriate software installed, you can ...

Sodium hypochlorite (NaOCl) is the main irrigant used in endodontic clinical practice, as it has excellent antimicrobial action and the ability to dissolve organic tissue 3. However, its great ...

Previously known as JNJ-2113, icotrokinra (Protagonist Therapeutics, Johnson & Johnson) has a very specific mechanism of action for the treatment of moderate to severe plaque psoriasis, according ...

The exact mechanism of the hypotensive action of chlorothiazide is not yet clear. In some publications it is claimed to be independent of the simultaneous natriuretic effect of the drug.

Joshua K. Sabari, MD, describes the mechanism of action of lurbinectedin as a synthetic alkaloid that binds to guanine residues in the minor groove of DNA, forming adducts that disrupt DNA repair ...

Sodium channel blockers can help reduce abnormal electrical activity in the heart. Learn more about the three main types and their specific uses.

Among the irrigation solutions used in Endodontics, sodium hypochlorite (NaOCl) is the most widely used. As its main features, it has an excellent antibacterial action and tissue dissolution capacity ...

These findings provide insights into paracetamol’s peripheral mechanisms of action and highlight the potential of AM404 as a pain-selective local anesthetic, offering broader implications for pain ...

However, the exact mechanism by which bulevirtide interacts with the virus entry receptor on the surface of the liver cells -- the bile salt transporter protein NTCP (short for: sodium ...