This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

BioAge has also filed a provisional patent application covering internally developed, novel small molecule APJ agonists. Apelin is an exercise-induced signaling molecule, known as an exerkine, which ...

Septerna is eligible to receive approximately 2.2 billion US dollars, including more than 200 million dollars in upfront and near-term payments South San Francisco, California, US and Bagsværd ...

“We were thrilled to find a small molecule that targets a killer protein called BAX and stops it working,” said co-corresponding author and the Head of WEHI’s New Medicine and Diagnostics ...

This evolving landscape is tightening its grip on an industry already struggling to keep pace with patient demand, and small molecule drug developers are feeling the pinch most acutely.

Breakthroughs in science tend to start with a small step. For scientists in Australia, a small step might offer new hope to patients who are suffering from neurodegenerative diseases such as ...

“Septerna has demonstrated strong capabilities in GPCR drug discovery, and we are excited about the opportunity to develop oral small molecule medicines directed at multiple targets.” GPCRs ...

A ceremony marking the start of construction on AstraZeneca's new small molecule drug factory is held in Wuxi, East China's Jiangsu province, on May 8. [Photo provided to chinadaily.com.cn ...

COPENHAGEN, May 14 (Reuters) - Novo Nordisk has struck a collaboration and licensing deal with U.S. biotech Septerna to develop oral small molecule medicines for obesity, type 2 diabetes and other ...

ASC47 is an adipose-targeted, ultra-long-acting SQ injected thyroid hormone receptor beta (THRβ) selective small molecule agonist, discovered and developed in-house at Ascletis. ASC47 possesses unique ...