A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart ...

A thiazolidine-modified nucleotide was synthesized for DNA sequencing by synthesis (SBS) through amidation of thiazolidine-2-carboxylic acid. The synthesized thiazolidine reversible terminator can ...

Accurate cell classification is crucial but expensive for large-scale single-cell RNA sequencing (scRNA-seq) analysis. Gene selection (GS) emerges as a pivotal technique in identifying gene subsets of ...