Recent studies revealed that SirT1 inhibits p53 and forkhead transcription factors 5,6,7,8,9, suggesting that SirT1 is involved in regulating cell survival and stress response in mammalian organisms.

In the Hot Papers featured here, several labs made a convincing case that SIRT1 regulates forkhead transcription factors (FOXOs) in mammals. Guarente's group showed that SIRT1 directly deacetylates ...

For example, SIRT1 chops off acetyl groups, which can inactivate the tumor suppressor p53. Yuan et al. determined SIRT1's effect on the transcription factor c-Myc, whose expression surges in many ...

Research investigates the effects of SIRT1 activation through resveratrol supplementation and energy restriction on vascular function in adults. The study reveals that both interventions increase ...

SIRT1 is known to suppress the activity of both NF-kappaB and p53, and since its dysregulation has been associated with models of several aging-related conditions, the research team focused on ...

Several mechanisms may account for the effects of SirT1 on inflammation in vitro: SirT1 can induce transcriptional silencing by deacetylating histone 3 at lysine 9 (H3K9) and histone 4 at lysine ...

HO-1 inhibits the activation of the TGF-ß/Smad3 pathway in NAFLD-related liver fibrosis through SIRT1. These findings provide insights into new therapeutic strategies for treating NAFLD ...

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Science Signaling , 2014; 7 (351): ra106 DOI: 10.1126 ...

To test the impact of a SIRT1-activating drug in depressed mice, Prof. Lu and team knocked out the SIRT1 gene in male rodents and examined their reaction to a sweet drink that they would usually ...

Enter Sinclair et al and the latest Science article. The group found an SIRT1 mutant with complete immunity to activator molecules such as resveratrol and synthetic compounds from GSK/Sirtris.

It activated p53-mediated apoptosis in multiple cancer cell lines. Similarly, studies have demonstrated inhibition of SIRT1 by CCAR2 through enhanced cellular Myc (c-MYC)-induced apoptosis ...