Deacetylation and reactivation of PGC-1α is mediated by the longevity-associated, NAD-dependent Sirt1 type III histone deacetylase. 37 – 39 PGC-1α is also methylated 40 and can be modulated by various ...

Decreased activity of eNOS, as Sirt1-mediated deacetylation of this enzyme boosts its activity.49. Upregulation of apoptosis and senescence, owing to the fact that Sirt1 promotes efficient DNA repair, ...

Citation: Frontiers Editorial Office (2025) Retraction: USP22 protects against myocardial ischemia–reperfusion injury via the SIRT1-p53/SLC7A11–dependent inhibition of ferroptosis–induced ...

SIRT1/P53 signaling axis is also one of the hotspots in CRC treatment. Numerous therapeutic mechanisms targeting SIRT1 have been explored. SIRT1 inhibitors, such as 4bb (Ghosh et al., 2017), MHY2245 ...

There are seven mammalian SIRTs (SIRT1 to SIRT7) with distinct subcellular locations. SIRT2 is mainly cytoplasmic; SIRT3, SIRT4, and SIRT5 are found in the mitochondrial compartment; and SIRT1, SIRT6, ...

SIRT1 is an NAD+-dependent deacetylase, whose activators have potential therapeutic applications in age-related diseases. Here we report a new class of SIRT1 activators. The activation is dependent on ...

High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over other deacetylases and NAD-processing ...