SHANGHAI, May 4, 2025 /PRNewswire/ -- On April 23, 2025, Nutshell Therapeutics ( Shanghai) Co., LTD. received IND clearance from the FDA to initiate Phase 1 clinical trial in the United States for its ...

It activated p53-mediated apoptosis in multiple cancer cell lines. Similarly, studies have demonstrated inhibition of SIRT1 by CCAR2 through enhanced cellular Myc (c-MYC)-induced apoptosis ...

To further confirm the relationship between circ-Sirt1 and senescence, VSMCs isolated from mouse aorta were treated with Ang II (100 nM) for 5 days to induced a senescence phenotype ().After chronic ...

Notably, TET1 depletion led to increased levels of the SIRT1-specifically controlled 382 and 120 acetylation sites on p53, which was inhibited by SIRT1 inhibitor EX527 treatment in vivo , suggesting ...

Kaempferia parviflora, branded Sirtmax, commonly known as black ginger. The paper was published in Communications Biology, and led by Tokiwa and the University of Tokyo’s Professor Koji Nagata. The ...

SIRT1 is a NAD + ‐dependent deacetylase that controls key metabolic and signaling pathways, including inactivating the p53 tumor suppressor. However, the mechanisms controlling SIRT1 enzymatic ...

The SIRT1/p53 pathway mediated cell apoptosis in many pathological processes. It has been reported that high concentration of glucose results in neuronal apoptosis through downregulation of SIRT1 and ...

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Science Signaling , 2014; 7 (351): ra106 DOI: 10.1126 ...

SIRT1 is known to suppress the activity of both NF-kappaB and p53, and since its dysregulation has been associated with models of several aging-related conditions, the research team focused on ...