The influence of the redox state on NPC cell-fate decisions was eliminated by removal of Sirt1 activity either by RNAi or through the use of Sirt1 inhibitors.

Sirtuin1 (SIRT1), a mammalian homolog of yeast Silent Information Regulator 2 (Sir2) and evolutionary conserved regulator of life span, positively affects self‐renewal ability of macrophages in vitro ...

High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over other deacetylases and NAD-processing ...