The arrest occurs from within G1, excluding contributions ... molecules to centrosomes (p53) in response to centrosome protein depletion is consistent with a role for centrosomes in the cell ...

We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin ...

Any problems that arise during this replication process can lead to damaged DNA, which can in turn cause growth arrest or ... loss of p53 in cancer cells that lack the G1 checkpoint." ...

The p53 gene is extremely important in cell biology as its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the “tumor suppressor gene.” However ...

The gene p53 ... role or roles of p53 in pluripotent stem cells is essential," he said. "Our goal was to finally resolve this question of whether p53 is essential for inducing cell cycle arrest ...

For example, MDM2 binds to TP53 mRNA, controlling the rate of translation, [24] and MDM2 regulates the levels of itself, MDM4 and p53. [23,25,26] The pivotal role of MDM2 and MDM4 in the control ...

An international team of scientists has studied whether Zmat3 could have critical functions that p53, the most important gene in preventing cancer, uses to prevent cancer. Anew study from the UPF ...

Any problems that arise during this replication process can lead to damaged DNA, which can in turn cause growth arrest or ... loss of p53 in cancer cells that lack the G1 checkpoint." ...