A surgeon can excise breast cancer from the body, but even the most skilled scalpel may not be able to remove every ...

The DGIST research team is the first to identify "switch proteins," which directly inhibit the function of NMDA receptors, and explain how the related mechanism works. The key clue this research ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University ...

A deeper mechanistic understanding of subcellular GPCR function holds significant promise for advancing drug discovery. Such ...